Yes, we always do laundry when staying at timeshares in the USA. We very much prefer to reserve a room with an in-room washer/dryer.
It's a very different story when traveling internationally and staying in hotels. Laundry "logistics" then become a very big issue. I will usually search internet discussions in advance of our trip for self-serve laundromats or inexpensive public laundries near out hotel. Sometimes we are still stuck doing some laundry in the room sink. I (the male) have purchased quick-dry clothing (shirts, pants, socks, undies) specifically for travel. It's much harder for my wife. She doesn't really like to send her clothes out, and she doesn't like to fully dry her clothes (she complains about shrinkage and wrinkling if she dries things completely).
However, over the past few years, Covid-19 seems to have solved this problem for us. Our last international trip was in early 2019. That seems to be the only good thing about Covid.