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Remdesivir

easyrider

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This morning Gilead anounsed that the Remdesivir trial went well. The market is liking this news. Stock for Gilead was suspended at opening today. So they have a cure and every thing can open. I think quarantine is officially over.

Bill
https://www.bloomberg.com/news/arti...r-trial-for-covid-19-has-met-primary-endpoint
 

WVBaker

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Dr. Scott Gottlieb, shortly after the Gilead news was released, described remdesivir as “part of a better toolbox” for dealing with the coronavirus. But he said on CNBC’s “Squawk Box” that it’s “not a home run, a cure by any means.”

“It’s not going to be a cure, but it is going to be a drug potentially that if you use it particularly early in the course of the disease ... it could reduce their chances of having a really bad outcome,” he said.

 

easyrider

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Only five days ago it wasn't looking too good for Remdesivir when reports came out that this drug didn't work. Today it is looking really good.

If you read the actual trial results you can see that the dose is only half of what was originally projected for the same result. The drug is safe to use for most people. Getting treatment before the full blown SARS sets in seems to have better results which seems logical.

Even though it may not be a "cure" , Remdesivir will be an effective treatment. Effective enough to stop quarantine measures in many areas of the life.

The problem with a vacine is even if there was a great vacine ready today it could not be manufactured today because of the supply line. The ingredients would not be readily available. Even the sand to make the medicinal grade glass is in short supply which seems odd.

Bill
 

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Good news. I'm not sure why the media is stuck on a cure. Maybe they don't understand how medicine/healthcare works.
 

CalGalTraveler

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That is hopeful news. If we know there is a treatment that works to reduce the severity and can treat early in the course of the disease that will be a great gain. Now we need faster and readily available testing so people can know they have it and an be treated early.

Did they say how fast they can produce for mass population?
 

CalGalTraveler

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BTW...We should be hearing soon about the famotodine (Pepcid) trial in NYC soon. They ran a molecule algorithm on a supercomputer and it was a top listed drug to potentially counteract Covid19. There also was a good result in Wuhan but that was not a double-blind rigorous study.

In the meantime, I am continuing to take Pepcid for my stomach. Perhaps it will protect in other ways. :)

 

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BTW...We should be hearing soon about the famotodine (Pepcid) trial in NYC soon. They ran a molecule algorithm on a supercomputer and it was a top listed drug to potentially counteract Covid19. There also was a good result in Wuhan but that was not a double-blind rigorous study.

In the meantime, I am continuing to take Pepcid for my stomach. Perhaps it will protect in other ways. :)


Guess what's next for hoarding and/or price gouging!

Ingrid
 

CalGalTraveler

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I am more inclined to risk it if there is an existing drug that is known to be safe and effective instead of a vaccine. The problem with a vaccine is that we don't know enough about side effects and long term issues. So *may* hold off until the full side effects of a vaccine are known.
 
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WVBaker

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That is hopeful news. If we know there is a treatment that works to reduce the severity and can treat early in the course of the disease that will be a great gain. Now we need faster and readily available testing so people can know they have it and an be treated early.

Did they say how fast they can produce for mass population?

So far only one of them, remdesivir, has been shown to have even potential effect on the disease that’s killed nearly 60,000 Americans. An announcement Wednesday by its maker, Gilead Sciences, said there was "positive data" from a study, but no further details have yet been provided.

Though a study published in the British medical journal The Lancet Wednesday found no clinical benefits to the drug.



Findings
Between Feb 6, 2020, and March 12, 2020, 237 patients were enrolled and randomly assigned to a treatment group (158 to remdesivir and 79 to placebo); one patient in the placebo group who withdrew after randomisation was not included in the ITT population. Remdesivir use was not associated with a difference in time to clinical improvement (hazard ratio 1·23 [95% CI 0·87–1·75]). Although not statistically significant, patients receiving remdesivir had a numerically faster time to clinical improvement than those receiving placebo among patients with symptom duration of 10 days or less (hazard ratio 1·52 [0·95–2·43]). Adverse events were reported in 102 (66%) of 155 remdesivir recipients versus 50 (64%) of 78 placebo recipients. Remdesivir was stopped early because of adverse events in 18 (12%) patients versus four (5%) patients who stopped placebo early.

Interpretation
In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits. However, the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies.

 

bluehende

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I saw a great interview with an ICU head nurse in NY. I wish I could find it to post. She was chronicling how far they have come in a few weeks. Her exact quote was a significant improvement in outcomes. I assume she did not elaborate because no real studies have been done. The one big change she chronicled was putting patients on their stomach and using much higher oxygenation instead of going onto ventilators. The best thing she said is we are learning more every day and we are doing better now and will be doing even better in the future even without a therapeutic.
 

Ralph Sir Edward

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So far only one of them, remdesivir, has been shown to have even potential effect on the disease that’s killed nearly 60,000 Americans. An announcement Wednesday by its maker, Gilead Sciences, said there was "positive data" from a study, but no further details have yet been provided.

Though a study published in the British medical journal The Lancet Wednesday found no clinical benefits to the drug.



Findings
Between Feb 6, 2020, and March 12, 2020, 237 patients were enrolled and randomly assigned to a treatment group (158 to remdesivir and 79 to placebo); one patient in the placebo group who withdrew after randomisation was not included in the ITT population. Remdesivir use was not associated with a difference in time to clinical improvement (hazard ratio 1·23 [95% CI 0·87–1·75]). Although not statistically significant, patients receiving remdesivir had a numerically faster time to clinical improvement than those receiving placebo among patients with symptom duration of 10 days or less (hazard ratio 1·52 [0·95–2·43]). Adverse events were reported in 102 (66%) of 155 remdesivir recipients versus 50 (64%) of 78 placebo recipients. Remdesivir was stopped early because of adverse events in 18 (12%) patients versus four (5%) patients who stopped placebo early.

Interpretation
In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits. However, the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies.


The one thing list that does disturb me is "Remdesivir was stopped early because of adverse events in 18 (12%) patients versus four (5%) patients who stopped placebo early." Tha implies that there may be a higher than acceptable drug reaction rate.
 

CalGalTraveler

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The Gilead trial had 1000 participants so it was well sized, and well designed compared to other studies which may not have had the rigor of this test e.g. some were retrospective, this Lancet study only had 237 participants so much smaller cohort.

The fact that Dr. Fauci is optimistic and compares this moment to AZT discovery for HIV is significant. They probably made a lot of adjustments from the first discovery on AZT treatment best practices, and I would expect the same of this drug.

IMO we are not out of the woods but at least we can see a potential path out.
 
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