Went with a four vowel opening word, and, to my surprise I hit on Y in position 3. With no other vowel hits, I started thinking this might be a word with Y as the only vowel.
Guess 2 was selected to suss whether Y was the only vowel, as well as to test for common consonants. Guess 2 confirmed a that Y was the only vowel, and gave me R and S as well. It also eliminated double Y words SLYLY and WRYLY, so I focused on words that had a Y in position 3 as the only vowel.
That left me stumped initially, but when I mentally shifted the R and S next to the Y, TRYST popped out.