The 'original' building (Berkeley) is the one they always show in the aerial picture of MMC. The rest of the buildings were Marriott designed, as the Berkeley was already constructed...and closest to the golf course, perhaps 200 yards away. Marriott owners get 6 golf rounds included, but you must rent a golf cart - single golfers rarely get a cart ($32) by themselves as they will probably be paired with other non-foursomes. As a result, the suites in this building are quite different ... and I believe the only building with widescreen TV (Yes, Manor Club is way behind in TV upgrades even with dramatic increases in MF over the last few years). The showers and jacuzzi tubs are much smaller too than in the Marriott designed buildings. On the other hand, the living room, kitchen, bedrooms, closets, etc. are much charger than the suites in the other buildings (at least in the 3 Berkeley suites I've had in the past).
My pref, like Charles, is more central ... on either side of the offices and close to the outdoor/indoor pools.
On the Sequel side, I've only stayed there once, I think I would prefer the 2nd building facing the very large pool area there as you'd be closer to the entrance to the pool, the BBQ section and tennis courts, etc. Sequel has lockoff suites, the original side is non-lockoff and looks much more Virginian.
The resort is in the middle of a very beautiful and challenging 54 hole golf course and there are not many balconies with a totally unobstructed view due to the fact there is a lot of tree growth in the way. Summertime is very very hot and humid there. Marketplace is open until 10 pm, later than most Marriott TS. The setting is very nice, but most places you go will need a car to get there ... Busch Gardens is perhaps a 15 minute drive. Lots to do in the area and more than you can do in a week, so be sure to prepare.
Hope that helps.
Brian