Paypal does not provide buyer protection for any type of real estate transaction, and they do classify vacation rentals as involving real estate. For vacation rentals, you are better served to pay directly with your own credit card or to use a verifiable third party escrow service to protect you. Be aware that even if you pay directly with your own card, there will likely be a window of opportunity to file a dispute. Most allow up to 90 days from time of payment. If your rental is further out than that- your dispute will most likely be rejected. If you read the PayPal terms and conditions, you'll find the following:
13.3 Ineligible Items. PayPal Purchase Protection only applies to PayPal payments for certain tangible, physical goods. Payments for the following are not eligible for reimbursement under PayPal Purchase Protection:
•Intangible items, including Digital Goods
•Services
•Real estate, including residential property
•Businesses
•Vehicles, including motor vehicles, motorcycles, caravans, aircraft and boats
•Custom-made items
•Travel tickets, including airline flight tickets
•Items prohibited by the PayPal Acceptable Use Policy
•Items which you collect in person or arrange to be collected on your behalf, including items bought through In-Store Checkout at the retail point of sale
•Items that violate eBay’s Prohibited or Restricted Items Policy
•Industrial machinery used in manufacturing
•Items equivalent to cash, including prepaid or gift cards
•PayPal Direct Payments
•Virtual Terminal Payments
•Personal Payments
Even if your payment is not eligible for PayPal Purchase Protection, you can file a Dispute and try to resolve the issue directly with the Seller; however, PayPal will generally not find in your favor if you escalate a Dispute to a Claim for an item which is not eligible for PayPal Purchase Protection.