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Hepatitis Surge in Young Children / May '21 Now Thought To Be Linked to COVID [MERGED]

T-Dot-Traveller

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I am 99.9 % sure
- that this thread will be shut down before there are answers to why this surge of Hepatitis in young children is occurring.
 

Tkhalaska

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I think the use of the term "hepatitis" is confusing. There is infectious hepatitis, like A,B,C, etc. There are vaccinations for types A & B. Then there is inflammatory hepatitis, which is not infectious in nature, it only means the liver is inflamed. Since these articles are only using the generic term "hepatitis" and not "hepatitis A,B,or C" then we are talking about inflamed livers.
Adenoviruses do cause inflammation, and were found in about half the children, however most of the kids were not vaccinated for covid, so a link to a vaccine like J&J is unlikely.
Possibilities are: A new strain of adenovirus that inflames the liver. Viruses mutate all the time, this woudn't be much of a surprise. OR this could be a new version of Multisystem Inflammatory Syndrome in Children ( MIS-C) associated with a history of infection with a new adenovirus or Covid ( symptomatic or asymptomatic), only preferentially affecting the liver.
I've taken care of kids with post-covid MIS-C and that seemed to mostly affect the heart, but that was also earlier in the pandemic so other variants could act differently.
 
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VegasBella

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  • This is definitely not a typical hepatitis. It's not caused by typical viruses that do it in healthy people, it's not caused by alcohol or tylenol.
  • These kids were not vaccinated. It's not the vaccines.
  • This is not a viral hepatitis. The bloodwork shows some adenovirus and some covid in kids along with other viruses, but not high viral loads that are typical of viral hepatitis.
  • The liver biopsies that were done did not show ANY virus - not adenovirus or sars2 etc. So if viruses are related it's likely an autoimmune/ immune mediated post-viral hepatitis.
  • The sequenced strains of adenoviruses do not match all the kids. If adenovirus is related, this definitely isn't just one strain like 41, the way it's being claimed in the media.
  • Adenovirus persists. It would be common to find it in kids who are ill with any type of hepatitis. Doesn't mean it's the culprit.
Regarding adenovirus, here is a twitter thread worth reading by a virologist:
 

VegasBella

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"A chain of events possibly triggered by unrecognized infection with the SARS-CoV-2 coronavirus could be causing the mysterious cases of severe hepatitis reported in hundreds of young children around the world, researchers suggest. Children with COVID-19 are at significantly increased risk for liver dysfunction afterward, according to a report posted on Saturday on medRxiv ahead of peer review"


The cited study is here https://www.medrxiv.org/content/10.1101/2022.05.10.22274866v1
 

VegasBella

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Israel study on young healthy kids getting Hepatitis...

"A new Israeli study focusing on pediatric hepatitis or severe liver inflammation in children suggests COVID may be the culprit. Dr. David Agus joins 'CBS Mornings' to discuss."
 

Cornell

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Analyses of four data sources did not indicate recent increases in hepatitis-associated ED visits or hospitalizations, liver transplants, or adenovirus 40/41 percent positivity among U.S. children compared with pre-COVID-19 pandemic levels

 

VegasBella

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fig2be5bbaad-0e4b-4ada-ae6b-daabf42ccdb9.png

Above is the WHO data for case rates worldwide by week.
You can see that USA is mostly week 20, which was mid-May. The CDC data shows a similar bump in May:
reported-patients-hepatitis-uknown-etiology.png




Below is the WHO data for the ages of the kids.

fig3.png

The children most impacted are 5 and under. These are also the children who until recently could not be vaccinated against Covid.
CDC is still not sharing data about whether or not these children have higher than average rates of Covid in their blood or stool samples.

Link to the WHO report: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON394
 
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