You cannot use resale points to qualify for VIP, or to qualify for a higher level. For the moment, if you have otherwise qualified for VIP, any resale points you add to your account are also extended the benefits that you already have. Expect that to change, though---sooner rather than later.
A resale-only purchaser also does not have access to Plus Partners without enrolling. An owner who has one developer purchase (or has otherwise enrolled any deed) has the Plus Partners attribute extended to all of their points.
That's about the only difference between the two.