Just S of Fort Meyers, rt 75 is being widened...and we had back ups....but did not go N of Ft Meters...so I don't know if construction is heavy there.
We drove down I 95 and there was construction in Palm Beach county (same as 75...widening the roads.
N of Martin Cty (I 95 north of Palm Beach) as you might be aware, itis three lanes N & S up to about Ft Pierce....then 2 lanes. It goes back to three lanes (AND CONSTRUCTION) in the Daytona area.....it is 3 lanes from this point all the way though many parts of GA....except parts of I 295 (5 lanes to 4 to 3 to 2) which go around Jacksonville.
As Jim pointed out, I 4 also has construction....but I don't know if it would be worth taking 75N to I 4 to I 95 N....but I do know that there was also some construction in GA, where they are still working on making the road wider...but it doesn't seem to affect traffic like in Fl. ie- in Fl, they may put up concrete barriers right into the lanes of traffic....in GA, they seem to work away from the traffic (except when there is overpasses).
If you can be sure I 4 is OK....or don't mind cutting across S fl on rt 60 (or 80-Palm Beach Blvd), I would use I 75 and cut to I 95 someplace after Palm Beach County. I 95, for most of your trip, is three lanes....and you may not be used to your new 5th wheel. (After this trip, you will be). Three lanes is more room....more passing if needed, and it seems GA is closer

from I 95