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Wyndham Grand Desert 77k, VV Williamsburg 4L/4 & 2/2
Former: Wyndham 276k, HGVC South Bend 1/1
The margins aren't quite as big as you suggest, though they are still there.
You aren't including employer payroll taxes, which are probably going to tack on another 10% or so on top of payroll. Then, depending on how the business is structured and operates (C Corp, S Corp, LLC) if she isn't on payroll she will also be paying Self-Employment tax, which is going to take about another 15% off of her income.
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Then there will be other general costs. If they have a physical office, there is rent for the office. There are office support costs - admin staff, accounting, human resources. If those aren't done in house (with office staff) then those will need to be contracted out. Business liability insurance will also need to be paid. Since medical services is a high risk field, I would expect that liability insurance is going to be between 5% and 10% of gross revenue, depending on deductibles. (I'm a self-employed professional engineer operating in significantly lower risk areas, and I pay about 4%.)
Off the top of my head, I would expect it costs her a minimum of $50,000 per year to keep the doors open.
I estimated $100k/yr for rent, utilities, and overhead. I forgot about insurance. But at about 10 percent, then her rent, utilities, overhead, and insurance would run $150k/yr. That means her salary is possibly $150k/yr.