Yup. My ASUS Eee701 has Skype built-in with it's Linux OS. It also has the included web-cam, but since I don't know anyone with a web-cam that I want to see while talking, I haven't tried it. Not all the ASUS Netbooks have a webcam. We use the Skype to access DW's office voice mail while traveling and that requires additional keypad inputs. We just use the number keys across the top of the keyboard. No problem. We DO use a headset.
If one has a Windows Netbook, a Magic Jack will work, too.
Jim Ricks